README.md

In keaven/simtrial: Clinical Trial Simulation

simtrial

Installation

You can install from GitHub:

remotes::install_github("Merck/simtrial")

Overview

simtrial is a small package built initially to focus on evaluating weighted logrank tests and combination tests based on such tests. The intent is to use tidyverse (data wrangling) programming procedures and to have a package that is easy to qualify for use in a regulated environment.

Initial areas of focus are:

• Generating time-to-event data for stratified trials using piecewise constant enrollment and piecewise exponential failure rates. Both proportional and non-proportional hazards are supported. Under proportional hazards, the assumptions are along the lines of those used by Lachin and Foulkes as implemented in the gsDesign for deriving group sequential designs.
• Setting up data cutoffs for (interim and final) analyses.
• Support for weighted logrank tests with arbitrary weighting schemes, specifically supporting the Fleming-Harrington set of tests, including the logrank test.

Future developments

Expectations for future development include:

• Provide a test suite to document that the package is fit for use in a regulatory environment.
• Further examples.

keaven/simtrial documentation built on April 17, 2023, 4:03 a.m.