lmna_nonseg: Nonsegregating _LMNA_ family data

In kinnamon-lab/FamModel: Regression Modeling for Family-Based Genetic Studies

Description

A dataset containing idiopathic DCM pedigrees with nonsegregating LMNA variants as well as other potentially relevant variants along with quantitative endophenotype measurements. Note that there were no twins in this data set.

Usage

lmna_nonseg

Format

A data.table with 88 rows and 13 columns:

• family_ID: Family ID

• proband: 1 = Yes, 0 = No

• individual_ID: Individual identifier (unique within family)

• paternal_ID: Individual_ID of person's father

• maternal_ID: Individual_ID of person's mother

• sex: 1 = Male, 2 = Female

• n_lmna_vars: # potentially relevant LMNA variants

• n_oth_vars: # potentially relevant non-LMNA variants

• grade: Phenotypic severity grade, 0 - 4 (see Cowan et al. 2018 reference)

• age_echo_yrs: Age at diagnostic echo, in years

• lvedd_z: Left ventricular end-diastolic dimension z-score (standardized for height and sex)

• lvef: Left ventricular ejection fraction, \

• mzpair: Same value for individuals who are MZ twins; NA otherwise

• dzpair: Same value for individuals who are DZ twins; NA otherwise

Source

https://bit.ly/lmna_nonseg

References

Cowan JR, Kinnamon DD, Morales A, Salyer L, Nickerson DA, Hershberger RE. Multigenic Disease and Bilineal Inheritance in Dilated Cardiomyopathy Is Illustrated in Nonsegregating LMNA Pedigrees. Circ Genom Precis Med. 2018 Jul;11(7):e002038. https://doi.org/10.1161/CIRCGEN.117.002038

kinnamon-lab/FamModel documentation built on April 26, 2021, 4:38 a.m.