README.md

In kjgleason/Mr.MtRobin: A Multi-Tissue transcriptome-wide Mendelian Randomization method ROBust to INvalid instrumental variables.

Mr.MtRobin: Multi-tissue transcriptome-wide Mendelian Randomization method ROBust to INvalid instrumental variables

The goal of Mr.MtRobin is to provide tools to conduct transcriptome-wide Mendelian randomization analysis using the MR-MtRobin algorithm. MR-MtRobin is a Multi-tissue transcriptome-wide Mendelian Randomization method ROBust to INvalid instrumental variables that takes summary statistics from complex trait GWAS and multi-tissue eQTL analyses as input and uses a reverse regression random slope mixed model to infer whether a gene is associated with a complex trait.

Setup

To install and load functions from Mr.MtRobin, run the following:

R devtools::install_github("kjgleason/Mr.MtRobin") library("Mr.MtRobin")

Citation

To cite Mr.MtRobin in publications, please use:

Kevin J. Gleason, Fan Yang and Lin S. Chen. A robust two-sample transcriptome-wide Mendelian randomization method integrating GWAS with multi-tissue eQTL summary statistics. Genet Epidemiol (2021); 45(4):353-371. doi:10.1002/gepi.22380.

kjgleason/Mr.MtRobin documentation built on Sept. 6, 2021, 5:13 p.m.