estimate_densities: Estimate parameters under the null and alternative densities

In kjgleason/Primo: Package in R for Integrative Multi-Omics association analysis

Description

Estimate the parameters of the null and alternative density functions. This function calls either estimate_densities_modT or estimate_densities_pval for density estimation using moderated t-statistics or P-values, respectively.

Usage

estimate_densities(betas = NULL, sds = NULL, df = NULL,
  pvals = NULL, alt_prop, mafs = NULL, N = NULL, use_tstats = TRUE)

Arguments

betas	vector of coefficient estimates.
sds	vector of standard errors (for coefficient estimates).
df	scalar or vector of first degrees of freedom of the F-distribution.
pvals	vector of P-values.
alt_prop	proportion of test statistics from the alternative density.
mafs	vector of minor allele frequencies (MAFs).
N	scalar or vector of number of subjects.
use_tstats	logical indicating whether to use moderated t-statistics (TRUE) or P-values (FALSE).

Value

See estimate_densities_modT or estimate_densities_pval.

kjgleason/Primo documentation built on Sept. 7, 2021, 3:58 a.m.