This package provides annotation for gene gene interaction importet from Reactome Data base.
4- Milacic M, Haw R, Rothfels K, Wu G, Croft D, Hermjakob H, D'Eustachio P, Stein L. Annotating cancer variants and anti-cancer therapeutics in reactome. Cancers (Basel). 2012 Nov 8;4(4):1180-211. doi: 10.3390/cancers4041180.
5- Croft D1, Mundo AF, Haw R, Milacic M, Weiser J, Wu G, Caudy M, Garapati P, Gillespie M, Kamdar MR, Jassal B, Jupe S, Matthews L, May B, Palatnik S, Rothfels K, Shamovsky V, Song H, Williams M, Birney E, Hermjakob H, Stein L, D'Eustachio P. The Reactome pathway knowledgebase. Nucleic Acids Res. 2014 Jan;42(Database issue):D472-7. doi: 10.1093/nar/gkt1102. Epub 2013 Nov 15.
devtools::github_install("kmezhoud/reactomeFI")
library(reactomeFI)
library(reactomeFI)
dim(ld_reactomeFI(2014))
[1] 217249 5
> dim(ld_reactomeFI(2015))
[1] 229300 5
> head(ld_reactomeFI(version= 2015))
Gene1 Gene2 Annotation Direction Score
1 16-5-5 CDC42 predicted - 0.82
2 16-5-5 RHOJ predicted - 0.82
3 16-5-5 RHOQ predicted - 0.82
4 <DELTA>FAS/APO-1/CD95 BID activate -> 1.00
5 <DELTA>FAS/APO-1/CD95 CASP10 complex - 1.00
6 <DELTA>FAS/APO-1/CD95 DAXX complex; reaction - 1.00
> tail(ld_reactomeFI(2015))
Gene1 Gene2 Annotation Direction Score
229295 ZP3 ZP4 complex - 1.00
229296 ZPR1 ZYX predicted - 0.59
229297 ZW10 ZWILCH complex; input - 1.00
229298 ZW10 ZWINT complex; input - 1.00
229299 ZWILCH ZWINT complex; input - 1.00
229300 ZXDA ZXDC predicted - 0.59
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