R/BWS_data.R

In lb664/MethylCal: MethylCal: Bayesian Calibration of Methylation Levels

#' Patients potentially affected by the Beckwith-Wiedemann syndrome
#' (BWS)
#'
#' Dataset containing human genomic control DNA (Promega), with five 
#' distinct actual methylation percentages (0\%, 25\%, 50\%, 75\% and 
#' 100\%) obtained by mixing different ratios of unmethylated and fully
#' methylated human control DNA, 15 healthy controls DNA and 18 patients
#' DNA.
#'
#' @docType data
#'
#' @usage data(BWS_data)
#'
#' @format A data frame consisting of nine independent assays in two
#' CpG islands located on SDHC gene promoter (SDHC_CpG:17 and SDHC_CpG:27)
#' and seven imprinted Differentially Methylated Regions (PLAGL1, GRB10, 
#' MEST, NRAP, H19/IGF2, KCNQ1OT1 and MEG3) with 115 CpG positions and 41 
#' variables:
#' \describe{
#'   \item{Target}{character: DMR/CpG island name}
#'   \item{Chrom}{integer: Chromosome}
#'   \item{CpG_pos}{integer: CpG position}
#'   \item{0.0\%, 25.0\%, 50.0\%, 75.0\%, 100.0\%}{numeric: Actual Methylation Percentages (AMPs)}
#'   \item{NC15, NC13, NC06, NC05, NC03, NC01, HC37, HC34, HC33, HC32, HC31, HC29, HC25, HC23, HC22}{numeric: Healthy controls}
#'   \item{B5A42, B5B37, B5C09, B5C06, B5C05, B5C41, B5C04, B5C31, B5C03, B5C28, B5C02, B5C19, B5C17, B5C14, B5C13, B5C12, B5C01, B5B38}{numeric: Patients potentially affected by the Beckwith-Wiedemann
#'         Syndrome (BWS)}
#' }
#'
#' @keywords Beckwith-Wiedemann syndrome dataset
#'
#' @references Ochoa E, Zuber V, Fernandez-Jimenez N, Bilbao JR, Clark 
#' GR, Maher ER, Bottolo L. MethylCal: Bayesian calibration of methylation
#' levels. Submitted. 2019.
#' 
#' @examples
#' data(BWS_data)
#' head(BWS_data)
"BWS_data"