pbcdata: Mayo Clinic Primary Biliary Cirrhosis Data
In magmarv18/pbcpkg: Yet Another Package Based on the Mayo Clinics PBC dataset

This data is from the Mayo Clinic trial in primary biliary cirrhosis (PBC) of the liver conducted between 1974 and 1984. A total of 424 PBC patients, referred to Mayo Clinic during that ten-year interval, met eligibility criteria for the randomized placebo controlled trial of the drug D-penicillamine. The first 312 cases in the data set participated in the randomized trial and contain largely complete data. The additional 112 cases did not participate in the clinical trial, but consented to have basic measurements recorded and to be followed for survival. Six of those cases were lost to follow-up shortly after diagnosis, so the data here are on an additional 106 cases as well as the 312 randomized participants.

pbcdata

A data frame with 418 rows and 20 variables:

id: case number
time: number of days between registration and the earlier of death, transplantion, or study analysis in July, 1986
status: status at endpoint, 0/1/2 for censored, transplant, dead
trt: 1/2/NA for D-penicillmain, placebo, not randomised
age: in years
sex: m/f
ascites: presence of ascites
hepato: presence of hepatomegaly or enlarged liver
spiders: blood vessel malformations in the skin
edema: 0 no edema, 0.5 untreated or successfully treated, 1 edema despite diuretic therapy
bili: serum bilirunbin (mg/dl)
chol: serum cholesterol (mg/dl)
albumin: serum albumin (g/dl)
copper: urine copper (ug/day)
alk.phos: alkaline phosphotase (U/liter)
ast: aspartate aminotransferase, once called SGOT (U/ml)
trig: triglycerides (mg/dl)
platelet: platelet count
protime: standardised blood clotting time
stage: histologic stage of disease (needs biopsy)