pr_adverse_evt: Simulate trial data

In maj-biostat/coadministr: Trial simulator for coadministration design

Description

Creates the trial data for rct comparing proportion of participants having moderate or adverse events associated with coadminstration of covid19 and flu relative to coadministration of covid19 and placebo.

Usage

pr_adverse_evt(pae_pbo = 0.02, pae_flu = 0.05, 
    pae_coad_az = 0, pae_coad_pf = 0,
    pae_az1 = 0.5, pae_az2 = 0.4,
    pae_pf1 = 0.3, pae_pf2 = 0.5)

Arguments

pae_pbo	Probability of 7 day AE PBO group (single dose)
pae_flu	Probability of 7 day AE FLU group (single dose)
pae_coad_az	Increase in Pr 7 day AE in CVD+FLU for AZ
pae_coad_pf	Increase in Pr 7 day AE in CVD+FLU for PF
pae_az1	Pr AE for first cvd dose cohort in AZ brand
pae_az2	Pr AE for second cvd dose cohort in AZ brand
pae_pf1	Pr AE for first cvd dose cohort in PF brand
pae_pf2	Pr AE for second cvd dose cohort in PF brand

Value

data.table containing timepoint, arm, cohort, probability of AE

Author(s)

Mark

Examples

## Not run: 
library(data.table)
library(coadministr)
# Same incr in Pr AE in CVD+FLU regardless of whether cvd dose 1 and dose 2
# cvd+flu combination increases pr AE by 0.1 for AZ
# cvd+flu combination increases pr AE by 0.15 for PF
b <- pr_adverse_evt(pae_pbo = 0.02, pae_flu = 0.05, 
                    pae_coad_az = 0.1, pae_coad_pf = 0.15,
                    pae_az1 = 0.5, pae_az2 = 0.4,
                    pae_pf1 = 0.3, pae_pf2 = 0.5)

## End(Not run)

maj-biostat/coadministr documentation built on Dec. 21, 2021, 1:44 p.m.