TrackSig, to estimate the evolutionary trajectories of signatures of somatic mutational processes. TrackSig uses cancer cell fraction (CCF) corrected by copy number to infer anapproximate order in which the somatic mutations accumulate. TrackSig segments mutation ordering by CCF and fits signature exposures (activities) as a piece-wise constant function of the mutation ordering. TrackSig uses optimal segmentation to find the points of change in signature activities.
|Author||Cait Harrigan, implemented with reference to TrackSig by Yulia Rubanova|
|Maintainer||Cait Harrigan <email@example.com>|
|Package repository||View on GitHub|
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