Description Usage Arguments Value
This function will construct a weighted nearest neighbor (WNN) graph. For each cell, we identify the nearest neighbors based on a weighted combination of two modalities. Takes as input two dimensional reductions, one computed for each modality.Other parameters are listed for debugging, but can be left as default values.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19  | FindMultiModalNeighbors(
  object,
  reduction.list,
  dims.list,
  k.nn = 20,
  l2.norm = TRUE,
  knn.graph.name = "wknn",
  snn.graph.name = "wsnn",
  weighted.nn.name = "weighted.nn",
  modality.weight.name = NULL,
  knn.range = 200,
  prune.SNN = 1/15,
  sd.scale = 1,
  cross.contant.list = NULL,
  smooth = FALSE,
  return.intermediate = FALSE,
  modality.weight = NULL,
  verbose = TRUE
)
 | 
object | 
 A Seurat object  | 
reduction.list | 
 A list of two dimensional reductions, one for each of the modalities to be integrated  | 
dims.list | 
 A list containing the dimensions for each reduction to use  | 
k.nn | 
 the number of multimodal neighbors to compute. 20 by default  | 
l2.norm | 
 Perform L2 normalization on the cell embeddings after dimensional reduction. TRUE by default.  | 
knn.graph.name | 
 Multimodal knn graph name  | 
snn.graph.name | 
 Multimodal snn graph name  | 
weighted.nn.name | 
 Multimodal neighbor object name  | 
modality.weight.name | 
 Variable name to store modality weight in object meta data  | 
knn.range | 
 The number of approximate neighbors to compute  | 
prune.SNN | 
 Cutoff not to discard edge in SNN graph  | 
sd.scale | 
 The scaling factor for kernel width. 1 by default  | 
cross.contant.list | 
 Constant used to avoid divide-by-zero errors. 1e-4 by default  | 
smooth | 
 Smoothing modality score across each individual modality neighbors. FALSE by default  | 
return.intermediate | 
 Store intermediate results in misc  | 
modality.weight | 
 A   | 
verbose | 
 Print progress bars and output  | 
Seurat object containing a nearest-neighbor object, KNN graph, and SNN graph - each based on a weighted combination of modalities.
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