calcParProtGOSim: Protein Sequence Similarity Calculation based on Gene...

In nanxstats/Rcpi: Molecular Informatics Toolkit for Compound-Protein Interaction in Drug Discovery

Protein Sequence Similarity Calculation based on Gene Ontology (GO) Similarity

Description

Protein Sequence Similarity Calculation based on Gene Ontology (GO) Similarity

Usage

calcParProtGOSim(
  golist,
  type = c("go", "gene"),
  ont = c("MF", "BP", "CC"),
  organism = "human",
  measure = "Resnik",
  combine = "BMA"
)

Arguments

golist	A character vector, each component contains a character vector of GO terms or one Entrez Gene ID.
type	Input type of golist, 'go' for GO Terms, 'gene' for gene ID.
ont	Default is 'MF', could be one of 'MF', 'BP', or 'CC' subontologies.
organism	Default is 'human', could be one of 'anopheles', 'arabidopsis', 'bovine', 'canine', 'chicken', 'chimp', 'coelicolor', 'ecolik12', 'ecsakai', 'fly', 'human', 'malaria', 'mouse', 'pig', 'rat', 'rhesus', 'worm', 'xenopus', 'yeast' or 'zebrafish'.
measure	Default is 'Resnik', could be one of 'Resnik', 'Lin', 'Rel', 'Jiang' or 'Wang'.
combine	Default is 'BMA', could be one of 'max', 'average', 'rcmax' or 'BMA' for combining semantic similarity scores of multiple GO terms associated with protein.

Details

This function calculates protein sequence similarity based on Gene Ontology (GO) similarity.

Value

A n x n similarity matrix.

See Also

See calcTwoProtGOSim for calculating the GO semantic similarity between two groups of GO terms or two Entrez gene IDs. See calcParProtSeqSim for paralleled protein similarity calculation based on sequence alignment.

Examples

# By GO Terms
go1 = c('GO:0005215', 'GO:0005488', 'GO:0005515', 'GO:0005625', 'GO:0005802', 'GO:0005905')  # AP4B1
go2 = c('GO:0005515', 'GO:0005634', 'GO:0005681', 'GO:0008380', 'GO:0031202')  # BCAS2
go3 = c('GO:0003735', 'GO:0005622', 'GO:0005840', 'GO:0006412')  # PDE4DIP
glist = list(go1, go2, go3)
calcParProtGOSim(glist, type = 'go', ont = 'CC', measure = 'Wang')

# By Entrez gene id
genelist = list(c('150', '151', '152', '1814', '1815', '1816'))
calcParProtGOSim(genelist, type = 'gene', ont = 'BP', measure = 'Wang')

nanxstats/Rcpi documentation built on Sept. 24, 2024, 9:36 a.m.