NEWS.md

In nlmixr2/babelmixr2: Use 'nlmixr2' to Interact with Open Source and Commercial Software

babelmixr2 (development version)

babelmixr2 0.1.6

• Use new nlmixr2est covariate selection enforcement for babelmixr2

• Fix a bug where the NONMEM export isn't working well (#839)

• Check loaded rxode2 information and compare to what the loaded model information should be. This allows better checking of which model is loaded and even more robust stability. It requires rxode2 > 3.0.2.

babelmixr2 0.1.5

• Fix bug where PopED could error with certain dvid values

• Fix bug where if/else clauses in the model could cause the model to not predict the values correctly.

• Fix bug so that shrinkage() calculation works

• Fix bug so that you can mix 2 different PopED data bases in an analysis without crashing R. While this didn't occur with every database clash, it more frequently occurred when you interleaved PopED code between two different PopED databases, like in issue #131.

• Added a new function babelBpopIdx(poped.db, "par") which will get the poped index for a model generated from babelmixr2, which is useful when calculating the power (as in example 11).

babelmixr2 0.1.4

• Added experimental PopED integration

• Removed dependence on rxode2parse

• Imported monolix2rx from the monolix2rx package

• Also allow conversion of a model imported from monolix to a nlmixr2 fit.

babelmixr2 0.1.3

• Changed default NONMEM rounding protection to FALSE

• Added a run option to the monolixControl() and nonemControl() in case you only want to export the modeling files and not run the models.

babelmixr2 0.1.2

• Handle algebraic mu expressions

• PKNCA controller now contains rxControl since it is used for some translation options

• This revision will load the pruned ui model to query the compartment properties (i.e. bioavailability, lag time, etc) when writing out the NONMEM model. It should fix issues where the PK block does not define some of the variables and will have a larger calculated variable that can be used in the model instead.

• When nonmem2rx has a different lst file, as long as nonmem2rx::nminfo(file) works, then a successful conversion to a nlmixr2 fit object will occur.

• Fix to save parameter history into $parHistData to accommodate changes in focei's output ($parHist is now derived).

• Changed the solving options to match the new steady state options in rxode2 and how NONMEM implements them. Also changed the iwres model to account for the rxerr. instead of the err. which was updated in rxode2 as well.

babelmixr2 0.1.1

• Add new method as.nlmixr2 to convert nonmem2rx methods to nlmixr fits

• Dropped pmxTools in favor of nonmem2rx to conserve some of the methods

babelmixr2 0.1.0

• Babelmixr has support for "monolix", "nonmem", and "pknca" methods on release.

• Added a NEWS.md file to track changes to the package.

nlmixr2/babelmixr2 documentation built on April 17, 2025, 11:46 a.m.