In olssol/cava: Clinical Trial Design for Cancer Vaccines

Installation

The package cava can be installed directly from CRAN:

install.packages("cava");

Some packages (e.g., shiny) are required to run the graphical user interface for visit, but are not required to run *cava through a R* terminal.

require(cava);
set.seed(10000);

Introduction

This is a clinical trial design software suite for cancer vaccines. The package currently includes two major designs for cancer vaccine clinical trials. The fist design is a Bayesian Phase I trial design that allows simultaneous evaluation of safety and immunogenicity outcomes in the context of vaccine studies. See Wang (2019) for the details of the Phase I cancer vaccine trial design. The second design is a batch-effect adjusted Simon two-stage design. This package's focus is the addition of batch-effect adjusted Simon two-stage design, where batch-effect is accounted for.

Conduct Simulation and Designs

baSimuBetaBin

Simulate batch data from Beta-Binomial with the given parameters.

baSimuBetaBin(4, 0.2, rho = 0.5);

baDesignBetaBin

Get designs from BetaBinomial designs with given parameters.

par.design <-  NULL;
par.design$P0 <- 0.2;
par.design$P1 <- 0.4;
par.design$ALPHA <- 0.5;
par.design$POWER <- 0.5;

baDesignBetaBin(par.design, rho = 1, bsizes = 2, nmin = 10, nmax = 20)

Graphical User Interface (GUI)

The cava package provides a web-based GUI for composite endpoint analysis. The GUI includes both cava and visit packages. The GUI can be accessed by