integrationSites: Two samples of viral integration sites.
In parsifal9/PPspectra: Energy Spectra and Coherence for Point Processes

X-linked severe combined immunodeficiency (SCID-X1) is an inherited disease caused by inactivating mutations in the gene encoding the interleukin 2 receptor common gamma chain (IL2RG), which is located on the X-chromosome. SCID-X1 gene therapy clinical trials were conducted in Paris and London. The clinical results differed and the question was raised of the effect of different transduction conditions on transduced cells. Human peripheral blood (PB) CD34+ cells were transduced with $gamma$-retroviral vectors according to the transduction protocols employed in the initial clinical trials. 14 Cells cultured under London trial conditions showed relatively higher retention of CD34 expression at the completion of the transduction period, compared to a loss of CD34-positivity in about half the cells transduced under the Paris trial conditions. Paris conditions, on the other hand, promoted higher levels of both proliferation and transduction, see Hallwirth.et.al.2015.

1	integrationSites

A list with two data frames

London: Distance along the genome (combined chromosomes) measued in basepairs. There are 72775 integration sites
Paris: Distance along the genome (combined chromosomes) measued in basepairs. There are 308538 integration sites

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Supplied by the authors

parsifal9/PPspectra documentation built on Dec. 31, 2020, 1:14 a.m.