Description Usage Arguments Examples
Bayes test of excess variant frequency with CADD-based prior
1 2 3 4 5 6 7 8 9 10 |
N.pair |
Matrix of 0/1/2 counts for sister pairs |
N.trio |
Matrix of 0/1/2/3 counts for sister trios |
vData |
data.table of variant info (ExAC frequencies and CADD scores) |
cutoff |
Exclude variants with ExAC frequencies above this cutoff |
ceiling |
Ceiling for prior |
floor |
Floor for prior |
rate |
Decay rate for prior |
Q |
Number of null simulations to run for q value calculation |
1 2 3 4 5 | N2 <- epcot_example$N2
N3 <- epcot_example$N3
vData <- epcot_example$vData
res <- bayesTest(N2, N3, vData)
head(res[order(res$FDR),])
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