PomaImpute: Impute Missing Values

In pcastellanoescuder/POMA: Tools for Omics Data Analysis

Impute Missing Values

Description

PomaImpute performs missing value imputation on a dataset using various imputation methods.

Usage

PomaImpute(
  data,
  zeros_as_na = FALSE,
  remove_na = TRUE,
  cutoff = 20,
  group_by = NULL,
  method = "knn"
)

Arguments

data	A SummarizedExperiment object.
zeros_as_na	Logical. Indicates if the zeros in the data are missing values. Default is FALSE.
remove_na	Logical. Indicates if features with a percentage of missing values over the cutoff parameter should be removed. Default is TRUE.
cutoff	Numeric. Percentage of missing values allowed in each feature.
group_by	Character. Indicates the name of the colData column to be used as the grouping factor. Default is NULL (no grouping). This variable specifies the grouping criteria for evaluating missing values. Missing values will be assessed within each group defined by this variable, and features will be removed only if all groups exceed the allowed threshold of missing values.
method	Character. The imputation method to use. Options include "none" (no imputation, replace missing values by zeros), "half_min" (replace missing values with half of the minimum value), "median" (replace missing values with the median), "mean" (replace missing values with the mean), "min" (replace missing values with the minimum value), "knn" (replace missing values using k-nearest neighbors imputation), and "random_forest" (replace missing values using random forest imputation).

Value

A SummarizedExperiment object without missing values.

Author(s)

Pol Castellano-Escuder

References

Armitage, E. G., Godzien, J., Alonso‐Herranz, V., López‐Gonzálvez, Á., & Barbas, C. (2015). Missing value imputation strategies for metabolomics data. Electrophoresis, 36(24), 3050-3060.

Examples

# Output is a imputed SummarizedExperiment object
data <- POMA::st000284 # Example SummarizedExperiment object included in POMA

# No sample normalization
data %>% 
  PomaImpute(zeros_as_na = FALSE,
             remove_na = TRUE,
             cutoff = 20,
             group_by = NULL,
             method = "knn")

pcastellanoescuder/POMA documentation built on Nov. 28, 2024, 1:21 p.m.