cyclicDoses: create intermittent dosing regimen

In philipdelff/pmxtricks: Every-day pharmacometrics helper functions

create intermittent dosing regimen

Description

create intermittent dosing regimen

Usage

cyclicDoses(hours.of.day, cycles.days, days.total, dose)

Arguments

hours.of.day	dosing time of day (hours)
cycles.days	list of numeric vectors. The vectors represent nested regimens. See details.
days.total	Total number of days for the regimen to continue.
dose	Will be copied to amt column

Details

• list(c(4,3)) means three days on, four days off.

• list(c(4,3),c(3,1)) means three days on, four days off for three cycles, then one cycle (of 4+3 days) off.

Examples

Complicated like ph2
dt <- cyclicDoseTab(c(0,12),cycles.days=list(c(4,3),c(21,7)),days.total=56,dose=400)
ggplot(dt,aes(times/24,amt))+geom_point()+geom_vline(xintercept=c(0,28,56))
## using cyclicDose to create a complex dosing regimen with rest days and rest weeks
dos1=cyclicDoses(c(0,12),cycles.days=list(c(4,3),c(21,7)),days.total=56,dose=400)
NMcreateDoses(TIME=dos1$TIME,AMT=dos1$AMT,CMT=2)

philipdelff/pmxtricks documentation built on Nov. 11, 2024, 5:16 p.m.