Description Usage Arguments Details Value
Obtain the operating characteristics of the Time-to-event gBOIN design for late-onset toxicity grades by simulating trials.
1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 | get.oc.tite.gBOIN(
target,
prob,
ncohort,
cohortsize,
maxt = 1,
prior.p = NA,
accrual = 3,
maxpen = 0.5,
alpha = 0.5,
startdose = 1,
cutoff.eli = 0.95,
ntrial = 1000,
seed = seed
)
|
target |
the target ETS |
prob |
a matrix containing the true toxicity probabilities of each grade x the investigational dose levels. |
ncohort |
the total number of cohorts |
cohortsize |
the cohort size |
maxt |
the maximum follow-up time |
prior.p |
a vector of length 3, which specifies the prior probability that the time to toxicity lies
inside the time interval (0, |
accrual |
the accrual rate, i.e., the number of patients accrued in 1 unit of time, |
maxpen |
the maximum proportion of pending patients |
alpha |
a number from (0,1) that controls alpha*100% events in (0, 1/2T).
The default is |
startdose |
the starting dose level for the trial |
cutoff.eli |
the cutoff to eliminate an overly toxic dose for safety.
We recommend the default value of ( |
ntrial |
the total number of trials to be simulated. |
seed |
set seed |
This function generates he operating characteristics of the Time-To-Event Bayesian Optimal Interval design for toxicity grades(TITE-gBOIN) with delayed toxicities grades by simulating trials under the prespecified true ETS of the investigational doses.
get.oc.tite.gBOIN()
returns the operating characteristics of the TITE-gBOIN design as a data frame,
including: (1) selection percentage at each dose level (selpercent
),
(2) the number of patients treated at each dose level (nptsdose
),
(3) the number of toxicities observed at each dose level (ntoxdose
),
(4) the average number of toxicities (totaltox
),
(5) the average number of patients (totaln
),
(6) the percentage of early stopping without selecting the MTD (pctearlystop
).
(7) the average trial duration needed for the trial based on the TITE-gBOIN design (duration
)
(8)the standard deviation of trial duration needed for the trial based on the TITE-gBOIN design (sdduration
)
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