Description Usage Arguments Details Value

Obtain the operating characteristics of the Time-to-event gBOIN design for late-onset toxicity grades by simulating trials.

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 | ```
get.oc.tite.gBOIN(
target,
prob,
ncohort,
cohortsize,
maxt = 1,
prior.p = NA,
accrual = 3,
maxpen = 0.5,
alpha = 0.5,
startdose = 1,
cutoff.eli = 0.95,
ntrial = 1000,
seed = seed
)
``` |

`target` |
the target ETS |

`prob` |
a matrix containing the true toxicity probabilities of each grade x the investigational dose levels. |

`ncohort` |
the total number of cohorts |

`cohortsize` |
the cohort size |

`maxt` |
the maximum follow-up time |

`prior.p` |
a vector of length 3, which specifies the prior probability that the time to toxicity lies
inside the time interval (0, |

`accrual` |
the accrual rate, i.e., the number of patients accrued in 1 unit of time, |

`maxpen` |
the maximum proportion of pending patients |

`alpha` |
a number from (0,1) that controls alpha*100% events in (0, 1/2T).
The default is |

`startdose` |
the starting dose level for the trial |

`cutoff.eli` |
the cutoff to eliminate an overly toxic dose for safety.
We recommend the default value of ( |

`ntrial` |
the total number of trials to be simulated. |

`seed` |
set seed |

This function generates he operating characteristics of the Time-To-Event Bayesian Optimal Interval design for toxicity grades(TITE-gBOIN) with delayed toxicities grades by simulating trials under the prespecified true ETS of the investigational doses.

`get.oc.tite.gBOIN()`

returns the operating characteristics of the TITE-gBOIN design as a data frame,
including: (1) selection percentage at each dose level (`selpercent`

),
(2) the number of patients treated at each dose level (`nptsdose`

),
(3) the number of toxicities observed at each dose level (`ntoxdose`

),
(4) the average number of toxicities (`totaltox`

),
(5) the average number of patients (`totaln`

),
(6) the percentage of early stopping without selecting the MTD (`pctearlystop`

).
(7) the average trial duration needed for the trial based on the TITE-gBOIN design (`duration`

)
(8)the standard deviation of trial duration needed for the trial based on the TITE-gBOIN design (`sdduration`

)

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