kmdata-package: kmdata

In raredd/kmdata: A Database of Reconstructed Individual Patient Level Data from Oncology Clinical Trials

kmdata

Description

Re-constructed Kaplan-Meier data from publications gathered on PubMed.

Details

Data sets were gathered from PubMed and limited to phase 3, randomized trials completed between January 1st 2014 and December 31st 2016 and published by JAMA Oncology, New England Journal of Medicine, Lancet, Lancet Oncology, Journal of Clinical Oncology, Annals of Oncology, Journal of the American Medical Association, or Journal of the National Cancer Institute.

The final list includes 304 figures from 153 publications. The data spans four cancers: colorectal, lung, prostate, and breast. All data sets feature time and event indicators as well as treatment arm (two arms per data set).

Additional information for each study is included in attributes of the data objects or in the key data, kmdata_key. The key includes publication identifiers, journal, title, outcome, sample size, etc.

This package also includes utilities to generate individual patient data (IPD) from digitized survival curve data using the method described by Guyot (2012); see ipd.

Author(s)

Maintainer: Robert Redd [e-mail]

Authors:

• Geoffrey Fell [e-mail]

• Rifaquat Rahman [e-mail]

See Also

kmdata_key for a list of the data sets available with some additional information about each including data source, outcomes, disease type, results, and quality of each re-capitulated data set.

summary for a method to summarize data sets

kmplot to plot Kaplan-Meier curves for each data set

select_kmdata to select studies based on characteristics listed in the kmdata_key

Examples

## all data sets included
data(package = 'kmdata')


## basic usage
summary(ATTENTION_2A)
kmplot(ATTENTION_2B)


## list of data sets estimating PFS
select_kmdata(Outcome %in% 'PFS')


## list of studies in breast cancer with fewer than 200 patients
l <- select_kmdata(Cancer %in% 'Breast' & ReportedSampleSize < 200, return = 'data')
op <- par(mfrow = n2mfrow(length(l)))
sapply(l, kmplot)
par(op)

raredd/kmdata documentation built on June 15, 2025, 9:33 a.m.