globalSeq-package: Negative binomial global test
In rauschenberger/globalSeq: Global Test for Counts
Description
Getting started
More information
Description
Testing for association between RNA-Seq
and other genomic data is challenging
due to high variability of the former
and high dimensionality of the latter.
Using the negative binomial distribution and a random effects model,
we developed an omnibus test that overcomes both difficulties.
It may be conceptualised as a test of overall significance
in regression analysis, where the response variable is overdispersed
and the number of explanatory variables exceeds the sample size.
The proposed method can detect genetic and epigenetic alterations
that affect gene expression. It can examine complex regulatory
mechanisms of gene expression.
Getting started
omnibus tests entire covariate sets
proprius shows individual contributions
cursus analyses the whole genome
The following command opens the vignette:
utils::vignette("globalSeq")
More information
A Rauschenberger, MA Jonker, MA van de Wiel, and RX Menezes (2016).
"Testing for association between RNA-Seq and high-dimensional data",
BMC Bioinformatics. 17:118.
html
pdf
(open access)
rauschenberger/globalSeq documentation built on May 19, 2020, 4:09 a.m.
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Description Getting started More information
Description
Testing for association between RNA-Seq and other genomic data is challenging due to high variability of the former and high dimensionality of the latter.
Using the negative binomial distribution and a random effects model, we developed an omnibus test that overcomes both difficulties. It may be conceptualised as a test of overall significance in regression analysis, where the response variable is overdispersed and the number of explanatory variables exceeds the sample size.
The proposed method can detect genetic and epigenetic alterations that affect gene expression. It can examine complex regulatory mechanisms of gene expression.
Getting started
omnibus tests entire covariate sets
proprius shows individual contributions
cursus analyses the whole genome
The following command opens the vignette:
utils::vignette("globalSeq")
More information
A Rauschenberger, MA Jonker, MA van de Wiel, and RX Menezes (2016).
"Testing for association between RNA-Seq and high-dimensional data",
BMC Bioinformatics. 17:118.
html
pdf
(open access)
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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