GetCorrelationMatrix: Get Z-scores Correlation Matrix
In rondolab/HOPS: The HOPS (HOrizontal Pleiotropy Score) package allows to compute the Horizontal pleiotropy score as described in Jordan et al.
Description
Usage
Arguments
Value
Warning
Author(s)
References
Examples
View source: R/GetCorrelationMatrix.R
Description
Allows to obtain the pairwise correlation matrix between Z-scores.
Usage
1
GetCorrelationMatrix(ZscoreMatrix)
Arguments
ZscoreMatrix
a data.frame of Z-scores with SNPs in rows and traits in columns. Careful no to include any column with SNP ids, only Zscores should be included.
Value
ZscoreCorMatrix
returns the pairwise correlation matrix between Z-scores
Warning
For further computation of the HOrizontal Pleiotropy Score (HOPS), only traits with a paiwise correlation level lower than 0.8 (in absolute value) should be included.
Author(s)
Marie Verbanck
References
Daniel Jordan*, Marie Verbanck* and Ron Do. HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases. Genome Biology 20, 222 (2019).
Examples
1
2
data(UKBiobank_ZscoresSubset)
ZscoreCorMatrixAllSNPs_UKBB <- GetCorrelationMatrix(ZscoreMatrix_UKBB)
rondolab/HOPS documentation built on July 30, 2020, 11:05 a.m.
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Description Usage Arguments Value Warning Author(s) References Examples
View source: R/GetCorrelationMatrix.R
Description
Allows to obtain the pairwise correlation matrix between Z-scores.
Usage
1 | GetCorrelationMatrix(ZscoreMatrix)
|
Arguments
ZscoreMatrix |
a data.frame of Z-scores with SNPs in rows and traits in columns. Careful no to include any column with SNP ids, only Zscores should be included. |
Value
ZscoreCorMatrix |
returns the pairwise correlation matrix between Z-scores |
Warning
For further computation of the HOrizontal Pleiotropy Score (HOPS), only traits with a paiwise correlation level lower than 0.8 (in absolute value) should be included.
Author(s)
Marie Verbanck
References
Daniel Jordan*, Marie Verbanck* and Ron Do. HOPS: a quantitative score reveals pervasive horizontal pleiotropy in human genetic variation is driven by extreme polygenicity of human traits and diseases. Genome Biology 20, 222 (2019).
Examples
1 2 | data(UKBiobank_ZscoresSubset)
ZscoreCorMatrixAllSNPs_UKBB <- GetCorrelationMatrix(ZscoreMatrix_UKBB)
|
R Package Documentation
Browse R Packages
We want your feedback!
Note that we can't provide technical support on individual packages. You should contact the package authors for that.
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