three.tail: Efficacy,toxicity and futility Stoping bound

In shrosehu/Continual-reassessment: Functions in this package help decide stopping rules in Phase 1 and Phase 2 clinical trials

Description

This function generats an efficacy stoping bound giving the parameters p and b.

Usage

three.tail(N, n1, p0, p1, ptox_l, ptox_u, lambda = 1, w, alpha, beta, gam)

Arguments

N	maximum sample size
n1	the sample size to start interim monitoring
p0	null response rate
p1	target response rate
ptox_l	a toxicity rate considered safe and we want to avoid stopping for safety under ptox_l
ptox_u	a toxicity rate above than ptox_u is overly toxic, requring immiediate stop
lambda	eff-tox correlation
w	weight
alpha	alpha
beta	beta
gam	probability of mistakenly stopping for toxicity when ptox<=ptox_l

Examples

three.tail(N=44, n1=1, p0=0.6, p1=0.8, ptox_l=0.05, ptox_u=0.35,w=0.5,alpha=0.05, beta=0.20,gam=0.1)

shrosehu/Continual-reassessment documentation built on June 30, 2020, 12:48 a.m.