inst/QueryLibrary/Aggregate/drug/D16.md

In sib-swiss/dsQueryLibraryServer: OMOP query Library

D16: Find drugs for an indication by indication type

Description

This query provides all drugs that are indicated for a certain condition. In addition, it provides the type of indication: FDA-approved, off-label (both based on FDB indication classes) and may treat and may prevent (both based on NDF-RT). Indications have to be provided as FDB indicationsor NDF-RT.

Query

SELECT DISTINCT
 drug.concept_id      as drug_concept_id,
 drug.concept_name    as drug_concept_name,
 drug.concept_code    as drug_concept_code,
 rn.relationship_name as indication_type,
 indication_relation.relationship_id
FROM
  @vocab.concept_relationship indication_relation
INNER JOIN @vocab.concept_ancestor a
 ON a.ancestor_concept_id=indication_relation.concept_id_2
INNER JOIN @vocab.concept drug
 ON drug.concept_id=a.descendant_concept_id
INNER JOIN @vocab.relationship rn
 ON rn.relationship_id=indication_relation.relationship_id
WHERE indication_relation.concept_id_1 = $1
  AND drug.domain_id = 'Drug'
  AND drug.standard_concept = 'S'
  AND indication_relation.relationship_id in (
          'May treat',
        'Is off-label ind of',
        'Is FDA-appr ind of',
        'Inferred class of',
        'May be prevented by',
        'May prevent',
        'Has FDA-appr ind',
        'Has off-label ind',
        'May be treated by',
        'Has inferred class');

Input

| Parameter | Example | Mandatory | Notes | | --- | --- | --- | --- | | Indication Concept ID | 4345991 | Yes | FDB indication concept for 'Vomiting' |

Output

| Field | Description | | --- | --- | | Drug_Concept_ID | Concept ID of the drug | | Drug_Concept_Name | Name of the drug | | Drug_Concept_Code | Concept code of the drug | | Indication_Type | One of the FDB, NDF-RT or OMOP inferred indication types | | Relationship_id | Corresponding relationship ID to the Indication Type |

Example output record

| Field | Value | | --- | --- | | Drug_Concept_ID | 19019530 | | Drug_Concept_Name | Perphenazine 4 MG Oral Tablet | | Drug_Concept_Code | 198077 | | Indication_Type | Inferred ingredient of (OMOP) | | Relationship_id | 281 |

Documentation

https://github.com/OHDSI/CommonDataModel/wiki/

sib-swiss/dsQueryLibraryServer documentation built on Feb. 13, 2025, 8:07 p.m.