NEWS.md

In sigven/oncoPharmaDB: Molecularly targeted cancer drugs and biomarkers

Version 1.8.8

• Removed buggy drug aliases from PubChem
• Updated DepMap RNA fusion events (24Q4)

Version 1.8.7

• NCI Thesaurus update (24.11d)
• CIViC update (20241218)
• New custom drug categories
• ICIs - CTLA4 inhibitors
• ICIs - TIGIT inhibitors
• ICIs - LAG3 inhibitors

Version 1.8.1

• CIViC update (20241107)
• NCI Thesaurus update (24.10d)

Version 1.8.0

• CIViC update (20241102)
• NCI Thesaurus update (24.09e)
• OTP update (2024.09)
• Clean-up of code for ChEMBL drug mappings
• skip DGIdb cross-references - rely on OTP

Version 1.7.3

• CIViC update (20240918)

Version 1.7.2

• CIViC update (20240904)

Version 1.7.1

• CIViC update (20240826)
• added location of MET exon 14 skipping splice site (grch37 principal transcript)

Version 1.7.0

• CIViC update (20240807)
• NCI Thesaurus update (24.07e)
• MitelmanDB update (20240715)
• New dataset: DepMap (cell line) RNA fusion events

Version 1.6.10

• Fixed some erroneous drug classifications
• CIViC update (20240621)
• OTP update (2024.06)

Version 1.6.8 (June 7th 2024)

• NCI Thesaurus update (24.05d)

Version 1.6.7 (May 23rd 2024)

• NCI Thesaurus update (24.04e)
• CIViC update (20240523)

Version 1.6.4 (April 30th 2024)

• Improved clinical (tumor site) annotations of fusions from MitelmanDB

Version 1.6.3 (April 26th 2024)

• CIViC update (20240426)

Version 1.6.2 (April 12th 2024)

• NCI Thesaurus update (24.03d)

Version 1.6.1 (March 26th 2024)

• Open Targets Platform update (v2024.03)

Version 1.6.0 (March 9th 2024)

• CIViC/Mitelmandb updates

Version 1.5.9 (February 29th 2024)

• Updated CIViC

Version 1.5.8 (February 6th 2024)

• NCI Thesaurus update (24.01e)

Version 1.5.7 (February 3rd 2024)

• Fixed buggy alias from PubChem

Version 1.5.6 (January 31st 2024)

• Refine possible values in treatment_category argument to get_drugs() function
• Fix anti-androgen classification
• Fixed bug in alias type notation for copy numbers and expression biomarkers
• Filter noise and rank output in helper function get_targeted_drugs
• Include variant primary name in biomarker variants

Version 1.5.0 (January 25th 2024)

• Considerable improvement of drug classifications (output column atc_level3), considering both targeted agents and chemotherapy
• argument drug_targeted_agent renamed to treatment_category
• helper function get_on_off_label_drugs renamed to get_targeted_drugs

Version 1.4.10 (January 17th 2024)

• Updated NCI Thesaurus (23.12d)
• Updated CIViC data (20240114)
• Revised manual drug classification (building upon ATC)

Version 1.4.8 (December 12th 2023)

• Updated NCI Thesaurus - 23.11d
• Updated CIViC data (20231212)

Version 1.4.8 (November 30th 2023)

• Updated OTP (v2023.12)
• Updated Mitelman database (20231016)

Version 1.4.7 (November 3rd 2023)

• Fixed corrupt biomarker literature data frame

Version 1.4.6 (October 18th 2023)

• Fixed metadata
• Fixed out-dated version descriptions (GH site)
• Do not exclude compounds with missing drug action type (platins etc.)

Version 1.4.5 (October 6th 2023)

• Updated NCI Thesaurus - 23.09d
• Updated CIViC data
• Added drug class (ATC) to get_on_off_label_drugs()

Version 1.4.4 (September 1st 2023)

• Updated NCI Thesaurus - 23.08d
• Updated CIViC data
• Updated Mitelman database (20230803)
• get_biomarkers() now exported as a main function

sigven/oncoPharmaDB documentation built on Dec. 24, 2024, 9:46 p.m.