tests/testthat/_snaps/castle_simple.md

In simondrue/castle: Fortify your ddPCR analyses for low-frequency variant detection

training model - snapshot

Code
  train_simple_ddpcr_model(background_samples = background_samples)
Output
  $a_est
  [1] 5.125098e-07

  $b_est
  [1] 8.088402e-07

  $c_est
  [1] 0.1132381

  $l_est_vec
  [1] 0.3036824 0.5045560 0.6623755 0.0000000

simulation - training - test

Code
  multiple_test_res
Output
    DoubleNegativeDroplets DoublePositiveDroplets WildtypeOnlyDroplets
  1                   7521                    644                 4889
  2                   8466                    152                 5252
    MutantOnlyDroplets mutant_molecules_per_droplet
  1                946                 0.1006261466
  2                130                 0.0004842163
    wildtype_molecules_per_droplet     p_val test_statistic mutation_detected
  1                      0.5028811 0.0000000   3172.7099905              TRUE
  2                      0.4877604 0.6735607      0.1774652             FALSE
    allele_frequency total_mutant_molecules total_wildtype_molecules
  1     0.1667356131            1408.766052                 7040.335
  2     0.0009917494               6.779028                 6828.645
    mutant_molecules_per_droplet_CI_lower mutant_molecules_per_droplet_CI_upper
  1                            0.09480199                           0.106645448
  2                            0.00000000                           0.002857597
    allele_frequency_CI_lower allele_frequency_CI_upper
  1                 0.1586158               0.174964409
  2                 0.0000000               0.005824486
    total_mutant_molecules_CI_lower total_mutant_molecules_CI_upper
  1                        1327.228                      1493.03627
  2                           0.000                        40.00636
    wildtype_molecules_per_droplet_CI_lower
  1                               0.4895578
  2                               0.4746937
    wildtype_molecules_per_droplet_CI_upper
  1                               0.5164573
  2                               0.5010782

simondrue/castle documentation built on Jan. 29, 2022, 3:04 a.m.