compute_extended_ratios: Compute extended set of biomarker ratios

In sritchie73/ukbnmr: Removal of Unwanted Technical Variation from UK Biobank NMR Metabolomics Biomarker Data

Compute extended set of biomarker ratios

Description

Computes 76 additional ratios not provided by the Nightingale platform. These include lipid fractions in HDL, LDL, VLDL, and total serum, as well as cholesterol fractions, and omega to polyunsaturated fatty acid ratios. See nmr_info for details.

Usage

compute_extended_ratios(x)

Arguments

x	data.frame containing NMR metabolomics data from UK Biobank. May either be raw field data output by ukbconv or data with column names corresponding to biomarkers listed in nmr_info.

Details

If your UK Biobank project only has access to a subset of biomarkers, then this function will only return the subset of ratios that can be computed from the biomarker data provided.

All biomarkers in the input data are also returned alongside the ratios computed by this function.

Value

a data.frame with the additional computed biomarker ratios.

See Also

nmr_info for list of computed biomarker ratios, compute_extended_ratio_qc_flags() for obtaining an aggregate of the biomarker QC flags from the biomarkers underlying each computed ratio, and extract_biomarkers() for details on how raw data from ukbconv is processed.

Examples

ukb_data <- ukbnmr::test_data # Toy example dataset for testing package
nmr <- compute_extended_ratios(ukb_data)

sritchie73/ukbnmr documentation built on Nov. 24, 2024, 8:51 p.m.