mendel_prob: mendel_prob

In statgenetics/mendelprob: Power Calculation for Mendelian Study

Description

Determine the probability of detecting a minimum number of families or unrelated cases with pathogenic variants in the same gene.

Usage

mendel_prob(num_probands = 0, num_probands_type_2 = 0, gene_freq = 0.005,
  min_num_variants = 2, min_num_probands_variants = 0)

Arguments

num_probands	number of probands
num_probands_type_2	number of unrelated cases
gene_freq	proportion of affected individuals explained by one gene
min_num_variants	minimum number of probands with pathogenic variant(s) in the same gene
min_num_probands_variants	minimum number of proband being a member of a family with pathogenic variant(s) in the same gene (cannot be bigger than min_num_variants)

Value

probability

Examples

mendel_prob(125, 500, 0.005, 2, 1)

statgenetics/mendelprob documentation built on May 6, 2019, 8:59 p.m.