ddmodel: diffDriver model

In szhaolab/diffdriver: Identify differential selection

diffDriver model

Description

This model is applied on data of a single gene. It will infer effect size for both sample-level variable and positional level functional annotations. We used an EM algorithm to infer parameters.

Usage

ddmodel(mut, e, mr, fe, label, ...)

Arguments

mut	a matrix of mutation status 0 or 1, rows positions, columns are samples.
e	a vector,phenotype of each sample, should match the columns of mut and mr
mr	a matrix, mutation rate of each sample at each mutation (log scale) that is not dependent on sample level factor
fe	a vector, increased mutation rate at each position, depending on e (log scale), should match the rows of mut and mr

szhaolab/diffdriver documentation built on June 1, 2025, 8:04 p.m.