PSCAN-package: Protein-structure-guided scan tests for detecting gene-level...

In tangzheng1/PSCAN: Protein-structure-guided scan method for detecting gene-level associations and signal variants

Description

PSCAN package has the main PSCAN function that implements protein-structure-guided scan (PSCAN) methods for detecting gene-level associations and signal variants.

Details

Package:	PSCAN
Type:	Package
Version:	1.1
Date:	2020-07-30
License:	GPL (>=2)

PSCAN

Author(s)

Zheng-Zheng Tang

Maintainer: Zheng-Zheng Tang <[e-mail]>

References

Tang ZZ, Sliwoski GR, Chen G, Jin B, Bush WS, Li B, and Capra JA. (2020). Spatial scan tests guided by protein structures improve complex disease gene discovery and signal variant detection. Genome Biology.

Examples

data(one.gene)
U = one.gene$U
V = one.gene$V
MAC = one.gene$MAC
weight = one.gene$weight
# perform PSCAN mean-based test and signal region detection
PSCAN(type="mean", U=U, V=V, MAC=MAC, weight=weight, N.MC=1000, FWER=0.05, plot3D=TRUE)

tangzheng1/PSCAN documentation built on Aug. 5, 2020, 2:12 p.m.