STAT210prob4.17: STAT210prob4.17: Drug Response from one Gene in Human...

In thoree/stat340: Data and functions for BIAS at NMBU

STAT210prob4.17: Drug Response from one Gene in Human Leukaemia Cells

Description

This data is from an article in Nature Genetics where they studied gene expression as a function of different treatments for leukaemia. The three treatment groups are: mercaptopurine (MP) only; low-dose methotrexate (LDMTX) and MP; and high-dose methotrexate (HDMTX) and MP. Each group contained ten subjects, and the responses from a specific gene are reported.

Usage

STAT210prob4.17

Format

A data frame with 30 observations (rows) and 3 variables (columns).

	Column name	Data type	Description	Values
[,1]	Project	integer	30 subjects, 10 per treatment group	(1 - 10)
[,2]	Treatment	factor	3 different treatments	(MP Only...MP + LDMTX)
[,3]	Gene_Expression	numeric	Gene expression for one gene	(23.6 - 1024.8)

Details

The data is from Exercise 4.17 in Design and Analysis of Experiments, 9th Edition, EMEA Edition.

Source

Montgomery, D. C. (2019) Design and Analysis of Experiments, 9th Edition, EMEA Edition. New York: Wiley.

References

Cheok, M.H., et al. (2003) Treatment-Specific Changes in Gene Expression Discriminate in vivo Drug Response in Human Leukemia Cells. Nature Genetics, 34, 85 – 90.

Examples

# The structure of the object
str(STAT210prob4.17)

# Number of subjects per treatment
table(STAT210prob4.17$Treatment)

# Expression of the gene for each treatment group
boxplot(Gene_Expression ~ Treatment, data = STAT210prob4.17,
        col = c("steelblue", "paleturquoise2", "khaki2"))

thoree/stat340 documentation built on June 30, 2024, 4:04 p.m.