hdl_subfractions: Effects of HDL subfractions on Coronary Artery Disease (CAD)

In tye27/mr.divw: debiased inverse-variance weighted estimator for univariable and multivariable Mendelian randomization

Effects of HDL subfractions on Coronary Artery Disease (CAD)

Description

It contains SNP-exposure and SNP-outcome association summary statistics from the following genome-wide association studies (GWASs):

1. Exposure dataset: A GWAS for traditional lipids http://csg.sph.umich.edu/willer/public/lipids2013/ (PubMed 24097068); A GWAS for subfractions http://www.computationalmedicine.fi/data\#NMR_GWAS (PubMed 27005778).

2. Outcome dataset: A GWAS for CAD from the CARDIoGRAMplusC4D consortium http://www.cardiogramplusc4d.org/data-downloads/ (PubMed 28714975).

3. Selection dataset: A GWAS for traditional lipids https://www.ebi.ac.uk/gwas/studies/GCST007141 (PubMed 29507422); A GWAS for subfractions http://csg.sph.umich.edu/boehnke/public/metsim-2017-lipoproteins/ (PubMed 29084231).

Usage

data(hdl_subfractions)

Format

A list with 3 elements with the first element being a data.frame with 24 columns (see below for column descriptions), the second element being an empty data.frame, the third element being an estimated correlation matrix.

SNP

SNP rsid

effect_allele

effect allele

other_allele

other allele

gamma_exp1,...,gamma_exp9

Estimated associations of each SNP with respectively traditional lipids HDL, LDL, TG, and HDL subfractions S-HDL-P, S-HDL-TG, M-HDL-P, M-HDL-C, L-HDL-P, and L-HDL-C.

se_exp1,...,se_exp9

Standard error estiamtes for gamma_exp1,...,gamma_exp9

gamma_out1

Estimated SNP-outcome association

se_out1

Standard error estimate for gamma_out1

selection_pvals

p-values for SNP-exposure associations in the selection dataset

Source

https://github.com/tye27/mr.divw

tye27/mr.divw documentation built on Oct. 18, 2024, 12:06 a.m.