disease_tissue_zscores: Disease-associated tissue scores.

In vittoriofortino84/ThETA: Transcriptome-based efficacy estimates of target(gene)-disease associations

Description

Significance of disease modules in tissue-specific interactomes.

Usage

data(disease_tissue_zscores)

Format

A list of numerical matrices.

Details

Significances were obtained by implementing the algorithm described in \insertRefKitsak2016ThETA, which aims to assess tissue specificity of human disease modules. It is a list of 5 matrices with EFO-id on the rows and GTEx-based tissues on the clomuns: - maxc: disease maximal connected components. - mer: averages of random maximal connected components. - sdr: standard deviations of random maximal connected components. - z: significances of disease-tissue associations in the form of Z-scores. - genes: cardinality of disease-relevant genes expressed in each tissue.

References

\insertRef

Failli2019ThETA

Examples

data(disease_tissue_zscores)
names(disease_tissue_zscores)
head(disease_tissue_zscores$z)

vittoriofortino84/ThETA documentation built on May 23, 2021, 4:24 a.m.