LiMACC: call LiMACC algorithm

Description Usage Arguments

Description

call LiMACC algorithm

Usage

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LiMACC(index_file, count_file, out_filename, comb_rep = "merge",
  dtype = "CHiC", peakFile4HiChIP = NULL, numG = 100,
  hcrc_pr = 0.9, fdr = 0.1, nIter = 20, maxN = 10000,
  minLen = NULL, maxLen = NULL, minDist = NULL, maxDist = 2 * 10^6,
  adj.method = "IHW", adjSeqDepth = NULL, updateMethod = "smooth")

Arguments

index_file

the name of restriction enzyme file for CHiC or index_file for HiChIP

count_file

contact map file(s)

out_filename

output file name

comb_rep

if length(count_file)>1, merge or pool replicates (default merge for CHiC; pool for HiChIP)

dtype

data type, CHiC/CC/HiChIP

peakFile4HiChIP

file of coordinate of 1D peak (bed file or similar format) for HiChIP, NULL for other type of data

numG

number of groups for limacc (default 100)

hcrc_pr

initial guess of backgound (default 0.9)

fdr

fdr cutoff used for the final output (default 0.05)

nIter

maxmimum number of iterations (default 20)

maxN

filter contacts that wiht more than maxN counts (default 100)

minLen

filter otherEnd fragments with length smaller than minLen

maxLen

filter otherEnd fragments with length greater than maxLen

adj.method

method for adjusting p-value (default 'IHW')

updateMethod

smooth or noupdate (default 'smooth')

sdepth

the number (in million) to which the sequence depth should be normalized, default NULL means do not adjust the total sequence depth


wbaopaul/limacc documentation built on Jan. 4, 2022, 2:31 a.m.