sim_mpp_single_locus: Simulate multiparental population (MPP) data from a specified...

In wesleycrouse/bmediatR: Toolset for running Bayesian mediation model selection analysis

Simulate multiparental population (MPP) data from a specified locus design matrix

Description

This function takes a locus design matrix, e.g., founder haplotypes dosages from CC mice, to simulate outcomes driven by its QTL.

Usage

sim_mpp_single_locus(
  locus_matrix,
  num_replicates,
  num_sim,
  qtl_effect_size = 0.1,
  strain_effect_size = 0,
  M_ID = NULL,
  sample_method = c("uniform", "crp"),
  num_alleles = 8,
  num_founders = 8,
  beta = NULL,
  impute = TRUE,
  sim_label = "sim_m",
  return_means = TRUE
)

Arguments

locus_matrix	A design matrix of founder haplotypes at QTL for MPP founder strains. The number of rows should correspond to the number of strains. The number of columns is eight for the CC/DO.
num_replicates	DEFAULT: 1. The number of strain replicates to use.
num_sim	DEFAULT: 1. The number of simulated outcomes to produce.
qtl_effect_size	DEFAULT = 0.1. The proportion of variation in the simulated outcomes explained by the QTL.

Examples

sim_cc_single_locus()

wesleycrouse/bmediatR documentation built on April 28, 2023, 4:01 p.m.