staar2scang_nullmodel: Transforming the null model object fitted using STAAR to the...

In xihaoli/STAARpipeline: STAARpipeline for Analyzing Whole-Genome/Whole-Exome Sequencing Data

Transforming the null model object fitted using STAAR to the null model object to be used for SCANG-STAAR

Description

The staar2scang_nullmodel function takes in the object from fitting the null model and transforms it to the object from fitting the null model to be used for SCANG-STAAR procedure.

Usage

staar2scang_nullmodel(obj_nullmodel)

Arguments

obj_nullmodel

an object from fitting the null model, which is either the output from fit_nullmodel function, or the output from fitNullModel function in the GENESIS package and transformed using the genesis2staar_nullmodel function.

Value

An object from fitting the null model for related samples to be used for SCANG-STAAR procedure, which is the output from fit_null_glmmkin_SCANG function for related samples in the SCANG package.

References

Li, Z., Li, X., et al. (2022). A framework for detecting noncoding rare-variant associations of large-scale whole-genome sequencing studies. Nature Methods, 19(12), 1599-1611. (pub)

Li, X., Li, Z., et al. (2020). Dynamic incorporation of multiple in silico functional annotations empowers rare variant association analysis of large whole-genome sequencing studies at scale. Nature Genetics, 52(9), 969-983. (pub)

Li, Z., Li, X., et al. (2019). Dynamic scan procedure for detecting rare-variant association regions in whole-genome sequencing studies. The American Journal of Human Genetics, 104(5), 802-814. (pub)

xihaoli/STAARpipeline documentation built on Feb. 9, 2025, 12:39 a.m.