README.md

In xue-hr/MRcML: Mendelian randomization method with constrained maximum likelihood.

MRcML for Independent Samples and Overlapping Samples

R package for Mendelian randomization with constraind maximum likelihood (MRcML) methods. Here is the reference for the original MRcML method with two independent samples: Constrained maximum likelihood-based Mendelian randomization robust to both correlated and uncorrelated pleiotropic effects. Here is the reference for the extension of MRcML method with overlapping samples: Combining Mendelian randomization and network deconvolution for inference of causal networks with GWAS summary data.

Installation

xue-hr/MRcML documentation built on Aug. 25, 2024, 4:24 p.m.