TScMLStage1: Fit First Stage Model for 2ScML

In xue-hr/TScML: Two-stage constrained maximum likelihood (2ScML) method.

Fit First Stage Model for 2ScML

Description

This function is used for fitting first stage model of 2ScML.

Usage

TScMLStage1(cor.D1Z1, Cap.Sigma.stage1, n1, p, ind.stage1, posdef = 1e-07)

Arguments

cor.D1Z1	A vector of length p, containing sample correlations (calculated with the first sample) between exposure D and p instruments.
Cap.Sigma.stage1	Sample correlation matrix between p instruments, could be calculated either with the first sample individual-level instruments data, or with the reference panel.
n1	First stage sample size.
p	Number of instruments.
ind.stage1	Indices of instruments relevant to exposure D.
posdef	A small positive constant to be added on diagonal of covariance matrix to ensure it is positive definite.

Value

A vector of length p, containing estimated effects from IVs to exposure D.

xue-hr/TScML documentation built on Feb. 4, 2025, 12:59 a.m.