music.iter.ct: Scaling bulk data and signature matrix and estimate cell type...

In xuranw/wdec: Multi-subject single cell deconvolution

Scaling bulk data and signature matrix and estimate cell type proportion

Description

Scaling bulk data and signature matrix and estimate cell type proportion

Usage

music.iter.ct(
  Y,
  D,
  S,
  Sigma.ct,
  iter.max = 1000,
  nu = 1e-04,
  eps = 0.01,
  centered = FALSE,
  normalize = FALSE
)

Arguments

Y	vector of bulk tissue expression
S	vector of Avg. Library size
Sigma.ct	matrix of Subject level variation with cross-cell-type covariance.
iter.max	numeric, maximum iteration number. Default is 1000
nu	regulation parameter, take care of weight when taking recipical by default nu = 0.0001.
eps	Threshold of convergence. Default is 0.01.
centered	logic, subtract avg of Y and D. Default is FALSE.
normalize	logic, divide Y and D by their standard deviation. Default is FALSE
X	matrix, Signature matrix

Value

a list same as nnls.weight.basic

xuranw/wdec documentation built on March 8, 2024, 2:41 p.m.