power.equivalence.md.plot: Plot power of Two One-Sided Tests Procedure (TOST) for...

In yelleKneK/MBESS: The MBESS R Package

Plot power of Two One-Sided Tests Procedure (TOST) for Equivalence

Description

A function to plot the power of the two one-sided tests prodedure (TOST) for various alternatives. (See also package equivalence, function tost.)

Usage

power.equivalence.md.plot(alpha, logscale, theta1, theta2, sigma, n, nu, title2)

Arguments

alpha	alpha level for the 2 t-tests (usually alpha=0.05). Confidence interval for full test is at level 1- 2*alpha
logscale	whether to use logarithmic scale TRUE or not FALSE
theta1	lower limit of equivalence interval
theta2	upper limit of equivalence interval
sigma	sqrt(error variance) as fraction (root MSE from ANOVA, or coefficient of variation)
n	number of subjects per treatment (number of total subjects for crossover design)
nu	degrees of freedom for sigma
title2	Title appearing at bottom of plot

Value

power

Plot of power of TOST (probability that (1-2*alpha) confidence interval will lie within (theta1, theta2) given sigma, n, and nu. Also returns matrix of 201 differences between theta1 and theta2 as first column, and power values corresponding to n for other columns.

Author(s)

Kem Phillips; [e-mail]

References

Diletti, E., Hauschke D. & Steinijans, V.W. (1991) Sample size determination of bioequivalence assessment by means of confidence intervals, International Journal of Clinical Pharmacology, Therapy and Toxicology, 29, No. 1, 1-8.

Phillips, K.F. (1990) Power of the Two One-Sided Tests Procedure in Bioquivalence, Journal of Pharmacokinetics and Biopharmaceutics, 18, No. 2, 139-144.

Schuirmann, D.J. (1987) A comparison of the two one-sided tests procedure and the power approach for assessing the equivalence of average bioavailability, Journal of Pharmacokinetics and Biopharmaceutics, 15. 657-680.

Examples

## Not run: 
# Suppose that two formulations of a drug are to be compared 
# on the regular scale using a two-period crossover design, 
# with theta1 = -0.20, theta2 = 0.20, rm(CV) = 0.20, and 
# we choose 
n<-c(9,12,18,24,30,40,60)

# corresponding to 
nu<-c(7,10,16,22,28,38,58)

# degrees of freedom.  We need to test bioequivalence at the 
# .05 significance level, which corresponds to having a .90 confidence
# interval lying within (-0.20, 0.20). This corresponds to 
# Phillips (1990),  Figure 3.  Use

power.equivalence.md.plot(.05, FALSE, -.2, .2, .20, n, nu, 'Phillips Figure 3')

# If the formulations are compared on the logarithmic scale with 
# theta1 = 0.80, theta2 = 1.25, and 

n<-c(8,12,18,24,30,40,60)

# corresponding  to 
nu<-c(6,10,16,22,28,38,58)

# degrees of freedom. This corresponds to Diletti, Figure 1c. Use

power.equivalence.md.plot(.05, TRUE, .8, 1.25, .20, n, nu, 'Diletti, Figure 1c')

## End(Not run)

yelleKneK/MBESS documentation built on Oct. 30, 2023, 1:13 p.m.