README.md

In zhonghualiu/DACT: Testing for mediation effects in genome-wide epigenetic studies.

DACT

This R package is used for testing mediation effects in genome-wide epigenetic studies.

Description

DACT is an R package for testing mediation effects in genome-wide epigenetic studies. DACT leverages the epigenome-wide data to estimate the relative proportions of the three null cases under the composite null hypothesis. The empirical null framework has been employed for large-scale inference.

Installation

library(devtools)
devtools::install_github("https://github.com/zhonghualiu/DACT")

Usage

## p_a and p_b are the p-value vectors for the exposure-mediator and mediator-outcome associations 
## in genome-wide epigenetic studies.
DACT(p_a,p_b,correction="JC")

Example

library(DACT)
p_a = runif(1e4) ## a p-value vector for the exposure-mediator associations
p_b = runif(1e4) ## a p-value vector for the mediator-outcome associations
res = DACT(p_a=p_a,p_b=p_b,correction="JC") ## a p-value vector for mediation effect testing

License

This software is licensed under MIT.

zhonghualiu/DACT documentation built on Feb. 14, 2023, 8:21 p.m.