RNOmni-help: RNOmni: Rank-Normal Omnibus Association Testing

In zrmacc/RNOmni: Rank Normal Transformation Omnibus Test

RNOmni: Rank-Normal Omnibus Association Testing

Description

Implementation of genetic association tests that incorporate the rank-based inverse normal transformation (INT) RankNorm. In direct-INT DINT, the phenotype itself is transformed. In indirect-INT IINT, phenotypic residuals are transformed. The omnibus INT OINT test adaptively combines the D-INT and I-INT tests into a single robust and statistically powerful procedure. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies." Biometrics, 2019. <https://doi.org/10.1111/biom.13214>.

Author(s)

Zachary R. McCaw

zrmacc/RNOmni documentation built on Aug. 18, 2022, 9:44 p.m.