RNOmni-package: RNOmni: Rank Normal Transformation Omnibus Test

In zrmacc/RNOmni: Rank Normal Transformation Omnibus Test

RNOmni: Rank Normal Transformation Omnibus Test

Description

Inverse normal transformation (INT) based genetic association testing. These tests are recommend for continuous traits with non-normally distributed residuals. INT-based tests robustly control the type I error in settings where standard linear regression does not, as when the residual distribution exhibits excess skew or kurtosis. Moreover, INT-based tests outperform standard linear regression in terms of power. These tests may be classified into two types. In direct INT (D-INT), the phenotype is itself transformed. In indirect INT (I-INT), phenotypic residuals are transformed. The omnibus test (O-INT) adaptively combines D-INT and I-INT into a single robust and statistically powerful approach. See McCaw ZR, Lane JM, Saxena R, Redline S, Lin X. "Operating characteristics of the rank-based inverse normal transformation for quantitative trait analysis in genome-wide association studies" \Sexpr[results=rd]{tools:::Rd_expr_doi("10.1111/biom.13214")}.

Author(s)

Maintainer: Zachary McCaw [e-mail] (ORCID)

See Also

Useful links:

• https://github.com/zrmacc/RNOmni

zrmacc/RNOmni documentation built on Nov. 13, 2024, 5:44 p.m.