cml: Chronic Myelogenous Leukemia survival data.
In multcomp: Simultaneous Inference in General Parametric Models

cml	R Documentation

Chronic Myelogenous Leukemia survival data.

Description

Survival in a randomised trial comparing three treatments for Chronic Myelogeneous Leukemia (simulated data).

Usage

data("cml")

Format

A data frame with 507 observations on the following 7 variables.

center: a factor with 54 levels indicating the study center.
treatment: a factor with levels trt1, trt2, trt3 indicating the treatment group.
sex: sex (0 = female, 1 = male)
age: age in years
riskgroup: risk group (0 = low, 1 = medium, 2 = high)
status: censoring status (FALSE = censored, TRUE = dead)
time: survival or censoring time in days.

Details

The data are simulated according to structure of the data by the German CML Study Group used in Hehlmann (1994).

Source

R. Hehlmann, H. Heimpel, J. Hasford, H.J. Kolb, H. Pralle, D.K. Hossfeld, W. Queisser, H. Loeffler, A. Hochhaus, B. Heinze (1994), Randomized comparison of interferon-alpha with busulfan and hydroxyurea in chronic myelogenous leukemia. The German CML study group. Blood 84(12):4064-4077.

Examples


if (require("coxme")) {
    data("cml")
    ### one-sided simultaneous confidence intervals for many-to-one 
    ### comparisons of treatment effects concerning time of survival 
    ### modeled by a frailty Cox model with adjustment for further 
    ### covariates and center-specific random effect.
    cml_coxme <- coxme(Surv(time, status) ~ treatment + sex + age + riskgroup + (1|center), 
                       data = cml)
    glht_coxme <- glht(model = cml_coxme, linfct = mcp(treatment = "Dunnett"), 
                       alternative = "greater")
    ci_coxme <- confint(glht_coxme)
    exp(ci_coxme$confint)[1:2,]
}

multcomp documentation built on Oct. 19, 2025, 3 p.m.