Description Usage Arguments Details Value Author(s) References See Also
Receptor occupancy is calculated from posititron emission tomography (PET) data as the treatment-induced relative change in the concentration of available (not occupied) receptors.
1 |
base |
is the baseline binding potential (BPND). |
drug |
is the post-treatment binding potential (BPND). |
baseSE |
is the standard error for the baseline BPND. |
drugSE |
is the standard error for the post-treatment BPND. |
base.drug.corr |
is the user-specified correlation between baseline and post-treatment binding potentials. |
Occupancy is calculated using the straightforward and well-known formula. If the standard errors for the two binding potentials are provided, then the delta method is used to approximate the standard error for the estimate of occupancy.
OCC |
is the percent drug occupancy. |
SE |
is the approximate standard error of the parameter estimate. |
Brandon Whitcher bwhitcher@gmail.com
Cunningham VJ, Rabiner EA, Slifstein M, Laruelle M (2010). Measuring drug occupancy in the absence of a reference region: the Lassen plot re-visited, Journal of Cerebral Blood Flow & Metababolism, 30, 46-50.
Passchier J, Gee A, Willemsen A, Vaalburg W, van Waarde A (2002). Measuring drug-related receptor occupancy with positron emission tomography, Methods, 27, 278-286.
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