DEsingle is an R package for differential expression (DE) analysis of single-cell RNA-seq (scRNA-seq) data. It defines and detects 3 types of differentially expressed genes between two groups of single cells, with regard to different expression status (DEs), differential expression abundance (DEa), and general differential expression (DEg). DEsingle employs Zero-Inflated Negative Binomial model to estimate the proportion of real and dropout zeros and to define and detect the 3 types of DE genes. Results showed that DEsingle outperforms existing methods for scRNA-seq DE analysis, and can reveal different types of DE genes that are enriched in different biological functions.
|Author||Zhun Miao <[email protected]>|
|Bioconductor views||DifferentialExpression GeneExpression Preprocessing RNASeq Sequencing SingleCell Software Transcriptomics|
|Date of publication||2018-09-21|
|Maintainer||Zhun Miao <[email protected]>|
|Package repository||View on Bioconductor|
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