Expression data from single cells, from adengue virus infection study by Zanini et al, #' 2018. The expression was filtered to get cells 12 hours after infection with #' a multiplicity of infection (moi) of 1 (dengue) or uninfected(ctrl). Gene counts were normalized via Bioconductor package "SCNorm".
An object of class
Gene expression has to be discretized for use in FCBF.
Zanini, F., Pu, S. Y., Bekerman, E., Einav, S., & Quake, S. R. (2018). Single-cell transcriptional dynamics of flavivirus infection. Elife, 7, e32942. PubMed
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data(scDengue) exprs <- SummarizedExperiment::assay(scDengue, 'logcounts') infection <- SummarizedExperiment::colData(scDengue) target <- infection$infection # Discretize gene expression discrete_expression <- as.data.frame(discretize_exprs(exprs)) fcbf_features <- fcbf(discrete_expression, target, thresh = 0.05, verbose = TRUE)
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