GOfuncR: Gene ontology enrichment using FUNC
Version 1.0.0

GOfuncR performs a gene ontology enrichment analysis based on the ontology enrichment software FUNC. GO-annotations are obtained from OrganismDb or OrgDb packages ('Homo.sapiens' by default); the GO-graph is included in the package and updated regularly (10-Apr-2018). GOfuncR provides the standard candidate vs. background enrichment analysis using the hypergeometric test, as well as three additional tests: (i) the Wilcoxon rank-sum test that is used when genes are ranked, (ii) a binomial test that is used when genes are associated with two counts and (iii) a Chi-square or Fisher's exact test that is used in cases when genes are associated with four counts. To correct for multiple testing and interdependency of the tests, family-wise error rates are computed based on random permutations of the gene-associated variables. GOfuncR also provides tools for exploring the ontology graph and the annotations, and options to take gene-length or spatial clustering of genes into account. From version 0.99.14 on it is also possible to provide custom annotations and ontologies.

Package details

AuthorSteffi Grote
Bioconductor views GO GeneSetEnrichment
MaintainerSteffi Grote <[email protected]>
LicenseGPL (>= 2)
Package repositoryView on Bioconductor
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GOfuncR documentation built on May 2, 2018, 2:48 a.m.