mbqnSimuDistortion: Perturbation of sample mean and scale

In MBQN: Mean/Median-balanced quantile normalization

Description

mbqnSimuDistortion adds a random perturbation of mean and scale to each column of a matrix.

Usage

mbqnSimuDistortion(x, s.mean = 0.05, s.scale = 0.01)

Arguments

x	a matrix or data frame.
s.mean	scatter of relative change of mean.
s.scale	scatter of realtive change in scale, i.e. 0.01 corresponds to 1 percent.

Details

Shift and scale the sample mean and standard deviation of a matrix. The perturbation of center and scale relative to mean and standard deviation of each sample are drawn from a Gaussian distribution |N(0,σ^2)| with σ_mean=s.mean and σ_scale=s.scale, respectively.

Value

List with:

x.mod	perturbed matrix
mx.offset	numeric array of shifts of the sample means
mx.scale	numeric array of relative scales of the sample standard deviations.

Author(s)

Ariane Schad

References

Brombacher, E., Schad, A., Kreutz, C. (2020). Tail-Robust Quantile Normalization. BioRxiv.

See Also

mbqnSimuData() for data generation.

Examples

set.seed(1234)
x <- mbqnSimuData("omics.dep")
df <- mbqnSimuDistortion(x)

MBQN documentation built on Nov. 8, 2020, 8:13 p.m.