MIMOSA-package: MIMOSA: Mixture Models for Single Cell Assays

In MIMOSA: Mixture Models for Single-Cell Assays

Description

MIMOSA implements mxitures of Dirichlet-multinomial or Beta-binomial models for paired count data from single–cell assays that typically arise in immunological studies. It can be used for ICS (Intracellular Cytokine Staining) assays to detect vaccine responders, for example, or to detect changes in proportions of cells expressing a gene, such as in Fluidigm Biomark Single–cell gene expression.

References

Greg Finak, Andrew McDavid, Pratip Chattopadhyay, Maria Dominguez, Stephen C De Rosa, Mario Roederer, Raphael Gottardo Mixture Models for Single Cell Assays with Applications to Vaccine Studies Biostatistics, 2013, http://biostatistics.oxfordjournals.org/content/early/2013/07/24/biostatistics.kxt024.abstract

See Also

MIMOSA, ConstructMIMOSAExpressionSet

MIMOSA documentation built on Nov. 12, 2020, 2:02 a.m.