OmicsMarkeR is an R package that provides functions for classification and
feature selection of 'omics' level datasets.
During my studies as a developing Systems Biologist I discovered there were often varied techniques to answer the same initial question, how can I classify high-dimensional data (i.e. metabolomics, proteomics, transcriptomics)? A second question usually posed in Biomarker investigations was which features are most important to such classification.
I initially pursued the repositories of CRAN and Bioconductor. I discovered
such wonderful packages such as
caret (which I highly recommend); however,
I was unable to find a means of systematically running multiple algorithms in
addition to stability metrics to provide confidence with features identified as
important. This is critical as there seemed little practical benefit to
classifying 2+ groups if the features identified varied between each test.
In my readings, I came upon an excellent chapter in the Lecture Notes of Computer Science Vol. 5212 entitled 'Robust Feature Selection Using Ensemble Feature Selection Techniques' by Yvan Sayes, Thomas Abeel, and Yves Van de Peer. From this chapter I decided to build this package, a tool to provide multiple multivariate classification and feature selection techniques complete with multiple stability metrics and aggregation techniques. In this manner, this package provides a way to systematically compare both data perturbation and function perturbation ensemble techniques complete with a harmonic mean of feature robustness and classification performance to evaluate the optimal model for the individual dataset. This following David Wolpert's 'No Free Lunch Theorem' as there is no single model that is appropriate for all problems.
I have made every effort to cite articles in which either the original technique was developed or applied. The interested reader, as well you should be, is highly encouraged to seek out these articles.
Stable version Bioconductor
if (!requireNamespace("BiocManager", quietly=TRUE)) install.packages("BiocManager") BiocManager::install("OmicsMarkeR")
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